Bijo Mathew Selected Research

Monoamine Oxidase (MAO)

8/2022	Revealing the role of the benzyloxy pharmacophore in the design of a new class of monoamine oxidase-B inhibitors.
5/2022	Exploration of the Detailed Structure-Activity Relationships of Isatin and Their Isomers As Monoamine Oxidase Inhibitors.
3/2022	Conjugated Dienones from Differently Substituted Cinnamaldehyde as Highly Potent Monoamine Oxidase-B Inhibitors: Synthesis, Biochemistry, and Computational Chemistry.
1/2022	Ameliorative effect of ethoxylated chalcone-based MAO-B inhibitor on behavioural predictors of haloperidol-induced Parkinsonism in mice: evidence of its antioxidative role against Parkinson's diseases.
1/2022	Development of 2D, 3D-QSAR and Pharmacophore Modeling of Chalcones for the Inhibition of Monoamine Oxidase B.
1/2022	Extended Double Bond Conjugation in the Chalcone Framework Favours MAO-B Inhibition: A Structural Perspective on Molecular Dynamics.
12/2021	Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations.
11/2021	Replacement of Chalcone-Ethers with Chalcone-Thioethers as Potent and Highly Selective Monoamine Oxidase-B Inhibitors and Their Protein-Ligand Interactions.
10/2021	Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors.
10/2021	Revealing the role of fluorine pharmacophore in chalcone scaffold for shifting the MAO-B selectivity: investigation of a detailed molecular dynamics and quantum chemical study.

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Bijo Mathew Research Topics

Disease

29	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2022 - 01/2014
25	Alzheimer Disease (Alzheimer's Disease) 05/2022 - 01/2019
13	Neoplasms (Cancer) 04/2022 - 01/2016
9	Nervous System Diseases (Neurological Disorders) 08/2022 - 01/2017
7	Parkinson Disease (Parkinson's Disease) 05/2022 - 01/2016
6	COVID-19 12/2022 - 01/2021
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 01/2020
4	Amyloid Plaque 08/2020 - 01/2019
4	Dementia (Dementias) 08/2020 - 12/2019
3	Infections 01/2022 - 11/2020
3	Neoplasm Metastasis (Metastasis) 01/2021 - 06/2020
3	Neuroinflammatory Diseases 01/2021 - 01/2020
3	Inflammation (Inflammations) 01/2021 - 01/2020
3	Cognitive Dysfunction 01/2020 - 01/2019
2	Body Weight (Weight, Body) 03/2022 - 01/2013
2	Brain Diseases (Brain Disorder) 02/2022 - 01/2022
2	Epilepsy (Aura) 01/2022 - 01/2016
2	Carcinogenesis 01/2021 - 01/2021
1	Communicable Diseases (Infectious Diseases) 12/2022
1	Cross Infection (Nosocomial Infection) 08/2022
1	Urinary Tract Infections (Urinary Tract Infection) 08/2022
1	Hypoxia (Hypoxemia) 06/2022
1	Autism Spectrum Disorder 02/2022
1	Neurodevelopmental Disorders 02/2022
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2022
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022
1	Parkinsonian Disorders (Parkinsonism) 01/2022
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2022
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2022
1	Neurologic Manifestations (Neurological Manifestations) 01/2022
1	Huntington Disease (Huntington's Disease) 01/2022
1	Stroke (Strokes) 01/2022
1	Depressive Disorder (Melancholia) 09/2021
1	Hepatocellular Carcinoma (Hepatoma) 07/2021
1	Adenocarcinoma 02/2021
1	Breast Neoplasms (Breast Cancer) 01/2021
1	Diabetic Neuropathies (Diabetic Neuropathy) 01/2021
1	Glioblastoma (Glioblastoma Multiforme) 01/2021
1	Vomiting 01/2021

Drug/Important Bio-Agent (IBA)

30	Monoamine Oxidase (MAO)IBA 08/2022 - 01/2014
9	Pharmaceutical PreparationsIBA 12/2022 - 01/2019
5	Biological ProductsIBA 08/2022 - 12/2020
5	EnzymesIBA 05/2022 - 01/2016
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2019
5	ChalconesIBA 10/2021 - 01/2019
4	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA 08/2022 - 08/2020
4	VaccinesIBA 02/2022 - 01/2020
4	Amyloid (Amyloid Fibrils)IBA 08/2021 - 12/2019
4	Amyloid beta-PeptidesIBA 09/2020 - 01/2020
3	Chalcone (Benzalacetophenone)IBA 03/2022 - 11/2020
3	AntioxidantsIBA 03/2022 - 03/2020
3	Biomarkers (Surrogate Marker)IBA 08/2021 - 01/2020
3	Cholinesterases (Cholinesterase)IBA 08/2021 - 01/2019
3	AcetylcholinesteraseIBA 01/2021 - 01/2019
3	Peptides (Polypeptides)IBA 03/2020 - 12/2019
2	IsoenzymesIBA 05/2022 - 10/2021
2	Haloperidol (Haldol)FDA LinkGeneric 01/2022 - 11/2020
2	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2021
2	Oxidoreductases (Dehydrogenase)IBA 08/2021 - 01/2020
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021 - 12/2019
2	Protein Isoforms (Isoforms)IBA 01/2021 - 01/2021
2	Serotonin (5 Hydroxytryptamine)IBA 12/2020 - 11/2020
2	tau Proteins (tau Protein)IBA 03/2020 - 01/2020
2	LigandsIBA 01/2020 - 01/2019
1	ThiosemicarbazonesIBA 12/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2022
1	1-dodecylpyridoxal (PLD)IBA 08/2022
1	Oxygen (Dioxygen)IBA 06/2022
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2022
1	phthalideIBA 05/2022
1	phthalimideIBA 05/2022
1	Heterocyclic Compounds (Compounds, Heterocyclic)IBA 04/2022
1	CreatinineIBA 03/2022
1	Urea (Carbamide)FDA LinkGeneric 03/2022
1	cystoneIBA 03/2022
1	Gentamicins (Gentamicin)FDA LinkGeneric 03/2022
1	HydrocarbonsIBA 02/2022
1	aviptadilIBA 02/2022
1	Petroleum (Crude Oil)IBA 02/2022
1	Carisoprodol (Soma)FDA LinkGeneric 01/2022
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2022
1	favipiravirIBA 01/2022
1	Mitochondrial DNA (mtDNA)IBA 01/2022
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022
1	remdesivirIBA 01/2022
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2022
1	NexusIBA 08/2021
1	2-(N-cyclohexylamino)ethanesulfonic acid (CHES)IBA 08/2021
1	PiperazineIBA 08/2021
1	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2021
1	polyolIBA 01/2021
1	wogoninIBA 01/2021
1	Ellagic AcidIBA 01/2021
1	4- Acetamido- 4'- isothiocyanatostilbene- 2,2'- disulfonic Acid (SITS)IBA 01/2021

Therapy/Procedure

10	Therapeutics 06/2022 - 01/2019
3	Drug Therapy (Chemotherapy) 01/2022 - 01/2021
2	Immunotherapy 07/2021 - 01/2020
1	Catheters 08/2022
1	Glycemic Control 01/2021
1	Operative Surgical Procedures 01/2021